Systematic review and meta-analyses of intensity-modulated radiation therapy versus conventional two-dimensional and/or or three-dimensional radiotherapy in curative-intent management of head and neck squamous cell carcinoma.

PLoS One · 2018 · PMC6034843 · PMID 29979726

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

of borderline significancep = 0.06so close (0.05 < p ≤ 0.1)

Overall, the use of IMRT was associated with a 24% relative reduction (HR = 0.76, 95%CI = 0.57–1.01) in the risk of loco-regional relapse compared to 2D/3D-RT ( Fig 4 ), which was statistically of borderline significance (p = 0.06) as the upper bound of the 95%CI was just touching the line of unity.

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highly significantno p-value reported

Nonetheless, this non-inferiority of IMRT for disease-related outcomes is reassuring in that the highly significant reduction in xerostomia is not occurring at the cost of disease control.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.