borderline significancep = 0.06
Univariate and multivariable analysis of genetic risk factors for leukemia-free survival and their interaction with other risk factors for leukemic transformation In univariate analysis of genetic risk factors, leukemia-free survival was predicted by karyotype ( p < 0.001), SRSF2 mutation ( p < 0.001), ASXL1 mutation ( p < 0.001), IDH1/2 mutations ( p = 0.005), and triple negative mutational status ( p = 0.005) (Table 3 ); U2AF1 Q157 mutations had no significance ( p = 0.8), while EZH2 mutations displayed borderline significance ( p = 0.06).