failed to reach significancep = 0.0174
While treatment with 10 μM and 50 μM H 2 O 2 caused an increase in PARP-1 cleavage that failed to reach significance, treatment with 100 μM, 150 μM and 200 μM H 2 O 2 resulted in 3 fold (p = 0.0174), 5 fold (p < 0.0001) and 9 fold (p < 0.0001) increases in PARP-1 cleavage respectively ( Fig. 2 D). 3.3.