highly significantp < 0.0001
However, when considering the cerebellum as reference region, correlations between DVR-1 based on AV shunt and IDIF were strong and highly significant in all regions ( r = 0.978, p < 0.0001 in striatum; r = 0.967, p < 0.0001 in cortex; r = 0.955, p < 0.0001 in hippocampus; r = 0.934, p < 0.0001 in thalamus) (Figure 2B and Supplementary Table 2 ).