E47 Governs the MYC-CDKN1B/p27<sup>KIP1</sup>-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16<sup>INK4A</sup> and Wild-Type p53.

Cell Mol Gastroenterol Hepatol · 2018 · PMC6039985 · PMID 30003124

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may be significantno p-value reported

This may be significant because, after T187 phosphorylation of CDKN1B/p27 KIP1 by CDK2, CKS1B mediates interaction between CDKN1B/p27 KIP1 and SKP2, leading to proteosomal degradation of CDKN1B/p27 KIP1 in the nucleus. 51 , 52 Indeed, in a remarkable feat of drug development, small-molecule inhibitors that target a pocket

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