Effects of collagen-derived bioactive peptides and natural antioxidant compounds on proliferation and matrix protein synthesis by cultured normal human dermal fibroblasts.

A highly significant decrease in MMP-1 protein levels in supernatants (Fig. 5a,b ) was seen in response to collagen peptides alone and the combination of all six ACTIVE constituents (All; 33.8 ± 3% of media control; Fig. 5a ) and all ten FORTE constituents (All; 47.4 ± 7% of media control; Fig. 5b ).

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