No association between DNA methylation and COPD in never and current smokers.

Nevertheless, they show that in their covariate-adjusted model, the association between COPD and DNA methylation remains highly significant.

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Of the CpG sites on the 27K array, 23 787 CpG sites were also present among the 420 938 CpG sites that passed quality control in our analysis, but all failed to reach significance (after applying FDR correction for multiple testing for 23 787 CpG sites as used by Qui et al ).

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