highly significantP = 0.002
In contrast, after removing the weight change attributable to litter size, there remained a highly significant increase in weight of HET pups produced from Eed del/del growing oocytes compared to HET pups produced from Eed wt/del oocytes ( t 34.8 = 3.44, P = 0.002) and WT pups produced from either Eed wt/del ( t 36.3 = 2.81, P = 0.008) or Eed wt/wt ( t 33.1 = 2.29, P = 0.03) growing oocytes (Fig. 3e ).