The fact that a significant prognostic impact is shown in the entire cohort ( n = 517), but only a borderline significance in the L0 and no impact in the L1 subcohorts can be explained by the relatively low case numbers with information about this point ( n = 120/ n = 75 for L1/L0; Table S2 ).
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The sentences
The mean expression levels in this cohort were relatively low for all probesets, with highly significant correlations among each other (not shown).