The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.

Mol Cell Biol · 2018 · PMC6048318 · PMID 29760282

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highly significantP = 1.25 × 10 −63actually significant

This highly significant enrichment for decreased association of HPL-2 in these regions ( P = 1.25 × 10 −63 ; chi-square test) indicates that in the majority of regions where TDP-1 affects HPL-2 localization, TDP-1's role is to maintain HPL-2's chromatin association.

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