Alzheimer disease pathology and the cerebrospinal fluid proteome.

The cutoff optimized the Youden index [ 41 ] of the ROC curve for the prediction of CDR categories (CDR = 0 versus CDR > 0) as previously reported [ 27 ], where the cutoff for CSF P-tau181/Aβ 1–42 ratio was further confirmed to be a highly significant predictor of cognitive decline.

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