Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation.

22 In general, only an increasing trend was observed in the levels of IL-1β and IL-6, which is consistent with Scharl group, who previously reported that PTPN2 has a minor role in IECs during inflammation. 10 Collectively, these data indicate that the loss of TC-PTP in the intestinal epithelium leads to a specific phenotype, which might not implicate the immune system as strongly as anticipated.

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