highly significantp -value = 3.34 × 10 −9
Recently, a meta-analysis of existing genome-wide association studies (GWASs) and two new GWASs of over 12,496 cases and 18,190 controls of European ancestry produced highly significant evidence of a strong association between the single-nucleotide polymorphism (SNP) rs4252707 (G/A) and non-glioblastoma glioma ( p -value = 3.34 × 10 −9 , OR = 1.19) 18 .