The analysis of variance of the model containing the significant coefficients (in addition to B, D and E that were added to keep a hierarchical order in the model) is presented in Table 1 . The calculated F value considering the regression mean square and the residual mean square (MS REG /MS RES ) is equal to 87.95, which is much higher than the tabulated F value (10, 8, 95% confidence level) of 3.35, indicating that the regression is highly significant.
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Optimization of biomass pretreatments using fractional factorial experimental design.
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