TCRβ-expressing macrophages induced by a pathogenic murine malaria correlate with parasite burden and enhanced phagocytic activity.

TCRβ expression by the macrophage correlates with parasite burden on day 3 post-Pb−A infection Remarkably, on day 3 post-infection, we noted a highly significant positive correlation (p≤0.01, R 2 = 0.96, Pearson r correlation) between the proportion of CD11b high CD14 + F4/80 + macrophages that express TCRβ and parasite burden in individual mice ( Fig 9 ); a smaller percentage of macrophages were TCRβ + CD3ε − in mice with low parasitemia compared to mice with high parasitemia.

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