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The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review.

BMC Musculoskelet Disord · 2018 · PMC6060474 · PMID 30045704

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an increasing trendno p-value reported
An increasing trend of bone involvement in syphilis was found in recent studies [ 3 , 4 , 30 , 47 – 55 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.