Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.

Finally, correlations between DRD1 – PDYN ( P = 2 × 10 −6 ), DRD2 – PDYN ( P = 2 × 10 −6 ), DRD1 – OPRK1 ( P = 2 × 10 −6 ), and DRD2 – OPRK1 ( P = 2 × 10 −6 ) were positive and highly significant (Fig. 4 a–d).

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