Kappa opioid receptor antagonism: Are opioids the answer for treatment resistant depression?

Ment Health Clin · 2018 · PMC6063454 · PMID 30155392

Europe PMC DOI

hedged sentence

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

a trend toward significanceP = .054so close (0.05 < p ≤ 0.1)

The respective HAM-D and MADRS scores for BUP/SAM 1:1 at baseline were 19.4 (2.7) and 26.4 (4.4), with a statistically significant change on HAM-D of −6.7 (3.4; P = .032) and a trend toward significance on MADRS −11.5 (6.5; P = .054).

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