PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants.

CPT Pharmacometrics Syst Pharmacol · 2018 · PMC6063742 · PMID 29920988

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a decreasing trendno p-value reported

In our previous study, the OCT1 expression level showed a decreasing trend in connection with the OCT1‐Arg61Cys (rs12208357) variant of OCT1; however, the sample size was too small to draw any conclusions (4 of 32 pediatric liver samples represented the OCT1‐Arg61Cys variant). 18 Nies et al . 48 (2009) reported that this variant strongly correlated with decreased OCT1 protein expression in adult liver tissue ( P < 0.0001).

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