Barely Significant
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S100B and LDH as early prognostic markers for response and overall survival in melanoma patients treated with anti-PD-1 or combined anti-PD-1 plus anti-CTLA-4 antibodies.

Br J Cancer · 2018 · PMC6070917 · PMID 29950611

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highly significantno p-value reported
Furthermore, the results were highly significant for S100B increases in patients with PD and decreases in patients with PR or CR, respectively.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.