Association of HLA-DR/DQ polymorphisms with schizophrenia in Tunisian patients.

32 A recent meta-analyses based on genome-wide association studies indicate highly significant associations with schizophrenia in the HLA region. 33 In explaining the mechanism of HLA and disease association, Roitt suggests that the disease occurs when a foreign antigen, capable of eliciting an immune response, is morphologically similar to an endogenous antigen (e.g., HLA-DR). 34 B-lymphocytes, containing fragments of endogenous antigens, bind to HLA molecules and then activate T-cell receptors, thereby provoking cytokine secretion.

also in 132,142 other papers