Barely Significant
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Contemporary outcomes of isolated bioprothestic mitral valve replacement for mitral regurgitation.

Open Heart · 2018 · PMC6074638 · PMID 30094035

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an increasing trendno p-value reported
(2) Patients who undergo MVR in the current era have high-risk features including a significant prevalence of comorbid conditions (hypertension, diabetes, anaemia, atrial fibrillation, prior sternotomy, coronary artery disease, coagulopathy and chronic renal insufficiency), and the prevalence of these comorbidities increased overtime, suggesting an increasing trend to treated sicker patients.

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