Incidence and Health Related Quality of Life of Opioid-Induced Constipation in Chronic Noncancer Pain Patients: A Prospective Multicentre Cohort Study.

Pain Res Treat · 2018 · PMC6077510 · PMID 30112202

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a decreasing trendno p-value reported

Indeed, opioid use in chronic noncancer pain (CNCP) treatment is recommended in several guidelines [ 5 – 7 ], and high prescription rates were observed in several countries of Europe and the United States in the last decade [ 8 – 10 ], although there has been a decreasing trend in prescription rates since 2011 [ 10 , 11 ].

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