Cladribine: Off-label disease modification for people with multiple sclerosis in resource-poor settings?

1 However, there may be significant ascertainment bias underestimating the true prevalence of MS in low- and middle-income countries (LMIC), as there is close to a 100-fold difference in the availability of magnetic resonance imaging (MRI) scanners between the Western Pacific (0.35/100,000) and Africa (0.004/100,000). 1 This makes it difficult to apply the most recent diagnostic criteria, involving imaging.

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