Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis.

Analysis of tumor cell proliferation, as assessed by Ki67 labeling index, showed that as compared with saline-treated tumors, those treated with TMZ alone showed a highly significant decrease of cell proliferation, whereas proliferation was inhibited to a less extent in tumors treated with TMZ plus QN (Fig. 8d, e ).

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