Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins.

PLoS Genet · 2018 · PMC6084815 · PMID 30091980

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highly significantP < 2.2x10 -16actually significant

DNA methylation at 84.7% of these sites was significantly associated with at least one common genetic variant using a stringent mQTL threshold (P < 1x10 -8 ) ( S2 Table ); this represented a highly significant enrichment for mQTL effects (P < 2.2x10 -16 ) compared to less-heritable DNA methylation sites (defined as those with A < 0.8), amongst which only 24.5% were associated with a mQTL variant.

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