Correlation of Betel Quid with Oral Cancer from 1998 to 2017: A Study Based on Bibliometric Analysis.

Chin Med J (Engl) · 2018 · PMC6085852 · PMID 30082530

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highly significantno p-value reported

Particularly, a series of studies were actively performed on oral squamous cell carcinoma, betel quid chewing, and expression, showing highly significant correlation and concentration.

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an increasing trendno p-value reported

Therefore, in Southeast Asian areas, OC is highly prevalent due to the ancient custom of chewing quid.[ 8 ] According to data from the National Central Cancer Registry of China, in 2009,[ 9 ] OC and throat cancer had a crude incidence of 3.28/100,000, with 4.15/100,000 for males and 2.39/100,000 for females, showing an increasing trend.[ 10 ] In Taiwan, China, the incidence of OC was approximately 27.4/100,000.[ 11 ] OC involves not only varying factors and stages but also aberrant expression of many genes in cancer development.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.