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The expression of genes contributing to pancreatic adenocarcinoma progression is influenced by the respective environment.

Genes Cancer · 2018 · PMC6086001 · PMID 30108682

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a worrying trendno p-value reported
In the last three decades, a worrying trend of increased cases of PDAC has been witnessed in developed nations, resulting in high death toll [ 2 ][ 3 ][ 4 ][ 5 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.