Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches.

52 In this study, it was observed that all experimental molecules were able to decrease cholesterol, LDL, and triglycerides and increase HDL in hyperlipidemic mice, but in particular, 4a showed highly significant reduction in serum cholesterol compared to standard with P <0.01, highly significant increase in HDL compared to standard with P <0.01, and significant reduction in LDL compared to standard with P <0.05 ( Table 2 ).

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