Applied diagnostics in liver cancer. Efficient combinations of sorafenib with targeted inhibitors blocking AKT/mTOR.

In these settings, targeted therapy provoked a robust inhibition of cell proliferation that occurred alongside a highly significant inhibition of PRAS40 and S6 activities, hence suggesting an important role for these molecules, which are downstream effectors of the AKT/mTOR pathway, in the biology of HCC (Figure 3D and Supplementary Table 7 ).

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