Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Four transporter activity GO terms, including ion channel activity, cation channel activity, substrate-specific channel activity, and cation transmembrane transporter activity, had borderline significant associations with lung cancer (Fisher’s exact test, P = 0.071, 0.073, 0.080, and 0.098, respectively) (Table 4 and Fig. 2 ).

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The gated channel activity term showed association with lung cancer risk with borderline significance (Fisher’s exact test, P = 0.088) (Supplementary Table 4 ).

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