Acute treatment with TPA023B (1 mg kg −1 , i.p.) caused a highly significant reduction in the number of scratching bouts (determined during the interval 15–210 min after drug injection) (Fig. 8a ; for potential effects of i.p.
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Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA<sub>A</sub> receptors.
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