A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk.

BMC Biol · 2018 · PMC6090961 · PMID 30071832

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highly significantno p-value reported

pylori genes, in which a highly significant association was found with gastric cancer included trmB (HP0747) , and the less well-annotated HP0709 and HP0468 . trmB , homologous to E. coli Yggh , encodes a predicted S-adenosylmethionine-dependent methyltransferase regulated by the H. pylori orphan response regulator HP1021 [ 33 ], presumably involved in the regulation of acetone metabolism.

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