Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition.

2 ) from infected ( n = 4) and non-infected ( n = 8) animals revealed for EAAT2, GluA2, Shank3, and GABA A R α1 a highly significant main effect of infection status ( F 1,10 = 12.93; p = 0.005, two-way repeated measures ANOVA with protein as a within-subject factor and infection status as a between-subject factor) while no significant effect of protein or interaction was observed (all p > 0.804).

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In the homogenates of hippocampal probes, we further observed a trend-wise downregulation of EAAT2 ( t 13,4 = 1.90; p = 0.039, one-tailed), while the t test-based comparisons failed to reach significance for GluA2 ( p = 0.101) and GluN2B ( p = 0.326).

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