Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling.

Although we did not observe a significant effect of treatment (sc-514 or IRB) on the number of α/β cells, there was a decreasing trend of α/β cells compared with that in the Angll-treated db/db group.

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We observed an increasing trend of the stimulatory index in min6 cells, although there was no significant change, and the basal, as well as stimulated, insulin secretion was significantly promoted by Irbesartan in the high glucose environment (22.2 mmol/L or 33.3 mmol/L).

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