JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling.

Epigenetics Chromatin · 2018 · PMC6097338 · PMID 30119689

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highly significantno p-value reported

However, our identification of Sfrp1 as a direct target of JARID2 is highly significant as we establish here that not only is Sfrp1 a direct target of JARID2 and the PRC2 complex in skeletal muscle cells, but that SFRP1 is sufficient to recapitulate the Wnt signaling block observed in JARID2 depleted cells.

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