A randomized trial of symptom-based management in Japanese patients with COPD.

Int J Chron Obstruct Pulmon Dis · 2018 · PMC6097828 · PMID 30147307

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an overall trendno p-value reported

There was an overall trend for patients with more severe COPD to step up their therapy, as evidenced by higher baseline symptoms and a greater risk of exacerbations.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.