Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway.

J Pineal Res · 2018 · PMC6099285 · PMID 29575122

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a small trendno p-value reported

There was a small trend toward enhanced myocardial oxidative stress (elevated superoxide anion production, increased MDA levels, and decreased MnSOD activity) in SIRT1 −/− diabetic hearts compared to diabetic hearts while the difference did not reach a significant level.

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