Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment.

Molecules · 2018 · PMC6099659 · PMID 29865267

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Acute and repeated combined intracerebroventricular (i.c.v.) treatment with basic fibroblast growth factor (FGF2) and the 5-HT1AR agonist 8-OH-DPAT produced evidence of robust and highly significant antidepressant-like actions in the FST [ 6 , 13 ] due to synergistic allosteric receptor–receptor interactions.

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