highly significantP < 1 × 10 −22
Strikingly, we found that 41.9% (1328 out of 3173 sites) were edited at significantly higher levels in the brain than in non-brain tissues ( P < 0.05, Wilcoxon test), which represented a highly significant enrichment for brain-specific editing compared to various negative controls (see ‘Materials and Methods’ section) ( P < 1 × 10 −22 , Fisher’s test) (Figure 5H and Supplementary File S1 ).