A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1.

PLoS Genet · 2018 · PMC6107291 · PMID 30102696

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highly significantP = 3.6 × 10 −8actually significant

However, we found that EFEMP1 expression in GTEx human thyroid tissue was positively correlated with the risk alleles of one of the 2p16.1 BA-associated SNPs, and that this correlation was highly significant (rs1346786, GTEx eQTL P = 3.6 × 10 −8 ).

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