The germline genetic component of drug sensitivity in cancer cell lines.

Nat Commun · 2018 · PMC6107640 · PMID 30139972

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marginal significanceno p-value reported

For example, our data replicate associations between BRCA1/2 LOF with olaparib 14 and cisplatin 15 , as well as between DPYD LOF and 5-fluorouracil 17 , and between WFS1 variants and cisplatin toxicity 16 at marginal significance levels (FDR < 10%, Supplementary Data 3 ).

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