Although we used GEE to adjust for the correlation between eyes of the same subject, the correlation between the two eyes was high, which increased the standard error estimate of parameters and caused their nonsignificance in the NPDR versus PDR model despite a highly significant AUC curve ( Tables 2 , 4 ).
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Statistical Model of Optical Coherence Tomography Angiography Parameters That Correlate With Severity of Diabetic Retinopathy.
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Many parameters such as fractal dimensions and vascularized vessel density previously shown to be of significance did not achieve significance in the final model. 4 , 5 , 9 , 10 , 13 , 15 , 25 , 26 In addition, many variables that were significant in the univariate analysis of the current study were not useful in the final model.