Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy.

Hum Reprod · 2018 · PMC6112575 · PMID 30052981

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highly significantno p-value reported

Our findings demonstrated a highly significant reduction, or in some cases total depletion, of spermatogonia in SCD patients treated with hydroxyurea.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.