<sup>125</sup>I seed brachytherapy versus external beam radiation therapy for the palliation of painful bone metastases of lung cancer after one cycle of chemotherapy progression.

Onco Targets Ther · 2018 · PMC6118334 · PMID 30214224

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an increasing trendno p-value reported

Reportedly, the rate of bone metastasis is as high as 30%–40%, and it continues to show an increasing trend. 1 , 2 Pain is the most common clinical symptom of skeletal metastases.

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