carcinoma of unknown primary site hereditary cancer syndromes liquid biopsy molecular diagnostics predictive markers review Russian Science Foundation 10.13039/501100006769 14-25-00111 Hereditary cancer syndromes Hereditary cancer syndromes compose a group of genetic defects, which render highly significant elevation of cancer risk; importantly, this risk is more or less organ-specific, which allows to arrange meaningful diagnostic and preventive interventions for germ-line mutation carriers.
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