In the largest pilot trial, of 20 adult patients with recurrent GBM treated with a ≤60 g/day carbohydrate restricted diet, 3 discontinued because of poor tolerability, 3 had stable disease after 6 weeks that lasted 11–13 weeks and 1 had a minor response, with an overall trend towards an increase in progression-free survival in patients with stable ketosis [ 94 ].
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