Based on Figure 4 A, it can be stated that compounds substituted in positions C (3) ’, C (3,4) ’, C (3,5) ’, or C (2,6) ’ showed an increasing trend of activity with the lipophilicity increase up to compound 6 (R = 3-CF 3 ), at which the activity achieved plateau and from approximately log k ≈ 0.5 had an insignificant increase.
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Synthesis and Spectrum of Biological Activities of Novel N-arylcinnamamides.
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