Two-Dimensional Proton Magnetic Resonance Spectroscopy versus J-Editing for GABA Quantification in Human Brain: Insights from a GABA-Aminotransferase Inhibitor Study.

Sci Rep · 2018 · PMC6123452 · PMID 30181656

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantp < 0.001actually significant

For 2D 1 H MRS and ProFit, ANOVA-RM analysis revealed highly significant changes for POC GABA levels in the CPP-115 cohort ( F 3,9 = 20.5, p < 0.001), but not for placebo ( F 3,3 = 1.5, p = 0.4).

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a trend towards significancep = 0.06so close (0.05 < p ≤ 0.1)

For MEGA-PRESS, the ANOVA-RM showed a trend towards significance for the CPP-115 group ( F 3,9 = 3.59, p = 0.06) but not for the placebo cohort ( F 3,3 = 0.21, p = 0.90).

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