GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca<sup>2+</sup> channels.

This reduction was small (10 mV), but may be functionally highly significant as exocytosis in human α ‐cells exhibits a strong dependence on voltage; at voltages below −10 mV, exocytosis decreases by 5% for every mV reduction of the depolarizing command (Ramracheya et al. 2010 ).

also in 132,142 other papers